Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth that accounts for somatic mutations, selection, drift and spatial constraint...

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Detalles Bibliográficos
Autores principales: Chkhaidze, Ketevan, Heide, Timon, Werner, Benjamin, Williams, Marc J., Huang, Weini, Caravagna, Giulio, Graham, Trevor A., Sottoriva, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687187/
https://www.ncbi.nlm.nih.gov/pubmed/31356595
http://dx.doi.org/10.1371/journal.pcbi.1007243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687187/
https://www.ncbi.nlm.nih.gov/pubmed/31356595
http://dx.doi.org/10.1371/journal.pcbi.1007243

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