Overexpression of human Atp13a2(Isoform-1) protein protects cells against manganese and starvation-induced toxicity

Mutations in ATP13A2 cause Kufor-Rakeb syndrome (KRS), a juvenile form of Parkinson’s disease (PD) with dementia. However, the mechanisms by which mutations in ATP13A2 cause KRS is not understood. The mutations lead to misfolding of the translated Atp13a2 protein and its premature degradation in the...

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Detalles Bibliográficos
Autores principales: Ugolino, Janet, Dziki, Kristina M., Kim, Annette, Wu, Josephine J., Vogel, Bruce E., Monteiro, Mervyn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687281/
https://www.ncbi.nlm.nih.gov/pubmed/31393918
http://dx.doi.org/10.1371/journal.pone.0220849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687281/
https://www.ncbi.nlm.nih.gov/pubmed/31393918
http://dx.doi.org/10.1371/journal.pone.0220849

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