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Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine era
Germline mutations in BRCA1 and BRCA2 (BRCA) genes confer high risk of developing cancer, especially breast and ovarian tumors. Since the cloning of these tumor suppressor genes over two decades ago, a significant amount of research has been done. Most recently, monoallelic loss-of-function mutation...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Sociedade Brasileira de Genética
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687356/ https://www.ncbi.nlm.nih.gov/pubmed/31067289 http://dx.doi.org/10.1590/1678-4685-GMB-2018-0104 |