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Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2

Proper connectivity of the nervous system requires temporal and spatial control of axon guidance signaling. As commissural axons navigate across the CNS midline, ROBO-mediated repulsion has traditionally been thought to be repressed before crossing, and then to become upregulated after crossing. The...

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Detalles Bibliográficos
Autores principales: Johnson, Verity, Junge, Harald J, Chen, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687390/
https://www.ncbi.nlm.nih.gov/pubmed/31392959
http://dx.doi.org/10.7554/eLife.46042