A new mutL homolog 1 c.1896+5G>A germline mutation detected in a Lynch syndrome‐associated lung and gastric double primary cancer patient

BACKGROUND: Mismatch‐repair genes (MMRs) ensure high fidelity in genome editing. Loss of function mutation of MMRs will lead to instability of the genome and increase the incidence of cancers. Human mutL homolog 1 (MLH1) is a member of the MMRs, and its mutation is found in Lynch syndrome (LS). In a...

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Detalles Bibliográficos
Autores principales: Chen, Xuyuan, Li, Xiang, Liang, Hongsen, Wei, Lichun, Cui, Qiang, Yao, Ming, Wu, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687634/
https://www.ncbi.nlm.nih.gov/pubmed/31207149
http://dx.doi.org/10.1002/mgg3.787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687634/
https://www.ncbi.nlm.nih.gov/pubmed/31207149
http://dx.doi.org/10.1002/mgg3.787

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