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A new mutL homolog 1 c.1896+5G>A germline mutation detected in a Lynch syndrome‐associated lung and gastric double primary cancer patient
BACKGROUND: Mismatch‐repair genes (MMRs) ensure high fidelity in genome editing. Loss of function mutation of MMRs will lead to instability of the genome and increase the incidence of cancers. Human mutL homolog 1 (MLH1) is a member of the MMRs, and its mutation is found in Lynch syndrome (LS). In a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687634/ https://www.ncbi.nlm.nih.gov/pubmed/31207149 http://dx.doi.org/10.1002/mgg3.787 |