Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

In voltage-gated potassium channels (VGKC), voltage sensors (VSD) endow voltage-sensitivity to pore domains (PDs) through a not fully understood mechanism. Shaker-like VGKC show domain-swapped configuration: VSD of one subunit is covalently connected to its PD by the protein backbone (far connection...

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Detalles Bibliográficos
Autores principales: Carvalho-de-Souza, João L., Bezanilla, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687735/
https://www.ncbi.nlm.nih.gov/pubmed/31395867
http://dx.doi.org/10.1038/s41467-019-11545-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687735/
https://www.ncbi.nlm.nih.gov/pubmed/31395867
http://dx.doi.org/10.1038/s41467-019-11545-7

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