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Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
In voltage-gated potassium channels (VGKC), voltage sensors (VSD) endow voltage-sensitivity to pore domains (PDs) through a not fully understood mechanism. Shaker-like VGKC show domain-swapped configuration: VSD of one subunit is covalently connected to its PD by the protein backbone (far connection...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687735/ https://www.ncbi.nlm.nih.gov/pubmed/31395867 http://dx.doi.org/10.1038/s41467-019-11545-7 |