The droplet size of emulsion adjuvants has significant impact on their potency, due to differences in immune cell-recruitment and -activation

Self-emulsification is routinely used for oral delivery of lipophilic drugs in vivo, with the emulsion forming in vivo. We modified this technique to prepare novel oil-in-water emulsions of varying droplet size and composition on bench to enable adjuvanted vaccine delivery. We used these formulation...

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Detalles Bibliográficos
Autores principales: Shah, Ruchi R., Taccone, Marianna, Monaci, Elisabetta, Brito, Luis A., Bonci, Alessandra, O’Hagan, Derek T., Amiji, Mansoor M., Seubert, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687744/
https://www.ncbi.nlm.nih.gov/pubmed/31395915
http://dx.doi.org/10.1038/s41598-019-47885-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687744/
https://www.ncbi.nlm.nih.gov/pubmed/31395915
http://dx.doi.org/10.1038/s41598-019-47885-z

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