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The droplet size of emulsion adjuvants has significant impact on their potency, due to differences in immune cell-recruitment and -activation
Self-emulsification is routinely used for oral delivery of lipophilic drugs in vivo, with the emulsion forming in vivo. We modified this technique to prepare novel oil-in-water emulsions of varying droplet size and composition on bench to enable adjuvanted vaccine delivery. We used these formulation...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687744/ https://www.ncbi.nlm.nih.gov/pubmed/31395915 http://dx.doi.org/10.1038/s41598-019-47885-z |