Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

Cystic Fibrosis (CF) is a recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins and endoplasmic reticulum (ER) stress, with activat...

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Detalles Bibliográficos
Autores principales: Lara-Reyna, Samuel, Scambler, Thomas, Holbrook, Jonathan, Wong, Chi, Jarosz-Griffiths, Heledd H., Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687873/
https://www.ncbi.nlm.nih.gov/pubmed/31428093
http://dx.doi.org/10.3389/fimmu.2019.01789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687873/
https://www.ncbi.nlm.nih.gov/pubmed/31428093
http://dx.doi.org/10.3389/fimmu.2019.01789

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