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Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation
Cystic Fibrosis (CF) is a recessive genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR mutations cause dysregulation of channel function with intracellular accumulation of misfolded proteins and endoplasmic reticulum (ER) stress, with activat...
Autores principales: | Lara-Reyna, Samuel, Scambler, Thomas, Holbrook, Jonathan, Wong, Chi, Jarosz-Griffiths, Heledd H., Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687873/ https://www.ncbi.nlm.nih.gov/pubmed/31428093 http://dx.doi.org/10.3389/fimmu.2019.01789 |
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