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KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion

Reduced adenosine triphosphate (ATP) levels in ischemic stroke constitute an upstream contributor to neuronal cell death. We have recently created a small chemical, named Kyoto University Substance 121 (KUS121), which can reduce cellular ATP consumption. In this study, we examined whether KUS121 has...

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Detalles Bibliográficos
Autores principales: Kinoshita, Hisanori, Maki, Takakuni, Yasuda, Ken, Kishida, Natsue, Sasaoka, Norio, Takagi, Yasushi, Kakizuka, Akira, Takahashi, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687885/
https://www.ncbi.nlm.nih.gov/pubmed/31395936
http://dx.doi.org/10.1038/s41598-019-47993-w