Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution

The majority of common variants associated with common diseases, as well as an unknown proportion of causal mutations for rare diseases, fall in noncoding regions of the genome. Although catalogs of noncoding regulatory elements are steadily improving, we have a limited understanding of the function...

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Detalles Bibliográficos
Autores principales: Kircher, Martin, Xiong, Chenling, Martin, Beth, Schubach, Max, Inoue, Fumitaka, Bell, Robert J. A., Costello, Joseph F., Shendure, Jay, Ahituv, Nadav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687891/
https://www.ncbi.nlm.nih.gov/pubmed/31395865
http://dx.doi.org/10.1038/s41467-019-11526-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687891/
https://www.ncbi.nlm.nih.gov/pubmed/31395865
http://dx.doi.org/10.1038/s41467-019-11526-w

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