Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

Replication stress, a hallmark of cancerous and pre-cancerous lesions, is linked to structural chromosomal aberrations. Recent studies demonstrated that it could also lead to numerical chromosomal instability (CIN). The mechanism, however, remains elusive. Here, we show that inducing replication str...

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Detalles Bibliográficos
Autores principales: Wilhelm, Therese, Olziersky, Anna-Maria, Harry, Daniela, De Sousa, Filipe, Vassal, Helène, Eskat, Anja, Meraldi, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687892/
https://www.ncbi.nlm.nih.gov/pubmed/31395887
http://dx.doi.org/10.1038/s41467-019-11584-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687892/
https://www.ncbi.nlm.nih.gov/pubmed/31395887
http://dx.doi.org/10.1038/s41467-019-11584-0

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