Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

Changes to islet cell identity in response to type 2 diabetes (T2D) have been reported in rodent models, but are less well characterized in humans. We assessed the effects of aspects of the diabetic microenvironment on hormone staining, total gene expression, splicing regulation and the alternative...

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Detalles Bibliográficos
Autores principales: Jeffery, Nicola, Richardson, Sarah, Chambers, David, Morgan, Noel G, Harries, Lorna W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687954/
https://www.ncbi.nlm.nih.gov/pubmed/31098640
http://dx.doi.org/10.1093/hmg/ddz094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687954/
https://www.ncbi.nlm.nih.gov/pubmed/31098640
http://dx.doi.org/10.1093/hmg/ddz094

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