Structure-based engineering of heparinase I with improved specific activity for degrading heparin

BACKGROUND: Heparinase I from Pedobacter heparinus (Ph-HepI), which specifically cleaves heparin and heparan sulfate, is one of the most extensively studied glycosaminoglycan lyases. Enzymatic degradation of heparin by heparin lyases not only largely facilitates heparin structural analysis but also...

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Detalles Bibliográficos
Autores principales: Zhang, Chuan, Yang, Bao-Cheng, Liu, Wen-Ting, Li, Zhong-Yuan, Song, Ya-Jian, Zhang, Tong-Cun, Luo, Xue-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688311/
https://www.ncbi.nlm.nih.gov/pubmed/31399136
http://dx.doi.org/10.1186/s12896-019-0553-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688311/
https://www.ncbi.nlm.nih.gov/pubmed/31399136
http://dx.doi.org/10.1186/s12896-019-0553-3

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