MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

BACKGROUND: The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyance from the cell membrane to the nucleus, the transcriptional and epigenetic me...

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Detalles Bibliográficos
Autores principales: Fufa, Temesgen D., Baxter, Laura L., Wedel, Julia C., Gildea, Derek E., Loftus, Stacie K., Pavan, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688322/
https://www.ncbi.nlm.nih.gov/pubmed/31399133
http://dx.doi.org/10.1186/s13072-019-0297-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688322/
https://www.ncbi.nlm.nih.gov/pubmed/31399133
http://dx.doi.org/10.1186/s13072-019-0297-2

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