The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy

Drosophila blue cheese (bchs) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and p62. bchs mutations lead to age-dependent accumulation of ubiquitinated inclusions and progressive neurodegeneration...

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Detalles Bibliográficos
Autores principales: Sim, Joan, Osborne, Kathleen A., Argudo García, Irene, Matysik, Artur S., Kraut, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688705/
https://www.ncbi.nlm.nih.gov/pubmed/31428609
http://dx.doi.org/10.3389/fcell.2019.00129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688705/
https://www.ncbi.nlm.nih.gov/pubmed/31428609
http://dx.doi.org/10.3389/fcell.2019.00129

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