Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translation factor eukaryotic initiation factor 5A (eIF5A). We show here that hypusinated eIF5A (eIF5A(H)) promotes the effi...

Descripción completa

Detalles Bibliográficos
Autores principales: Puleston, Daniel J., Buck, Michael D., Klein Geltink, Ramon I., Kyle, Ryan L., Caputa, George, O’Sullivan, David, Cameron, Alanna M., Castoldi, Angela, Musa, Yaarub, Kabat, Agnieszka M., Zhang, Ying, Flachsmann, Lea J., Field, Cameron S., Patterson, Annette E., Scherer, Stefanie, Alfei, Francesca, Baixauli, Francesc, Austin, S. Kyle, Kelly, Beth, Matsushita, Mai, Curtis, Jonathan D., Grzes, Katarzyna M., Villa, Matteo, Corrado, Mauro, Sanin, David E., Qiu, Jing, Pällman, Nora, Paz, Katelyn, Maccari, Maria Elena, Blazar, Bruce R., Mittler, Gerhard, Buescher, Joerg M., Zehn, Dietmar, Rospert, Sabine, Pearce, Edward J., Balabanov, Stefan, Pearce, Erika L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688828/
https://www.ncbi.nlm.nih.gov/pubmed/31130465
http://dx.doi.org/10.1016/j.cmet.2019.05.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688828/
https://www.ncbi.nlm.nih.gov/pubmed/31130465
http://dx.doi.org/10.1016/j.cmet.2019.05.003

Ejemplares similares