A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U(34)-thiolation. Despite amino acid sufficiency, tRNA-thiolation deficient cells appear amin...

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Detalles Bibliográficos
Autores principales: Gupta, Ritu, Walvekar, Adhish S, Liang, Shun, Rashida, Zeenat, Shah, Premal, Laxman, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688859/
https://www.ncbi.nlm.nih.gov/pubmed/31259691
http://dx.doi.org/10.7554/eLife.44795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688859/
https://www.ncbi.nlm.nih.gov/pubmed/31259691
http://dx.doi.org/10.7554/eLife.44795

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