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A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis
Cells must appropriately sense and integrate multiple metabolic resources to commit to proliferation. Here, we report that S. cerevisiae cells regulate carbon and nitrogen metabolic homeostasis through tRNA U(34)-thiolation. Despite amino acid sufficiency, tRNA-thiolation deficient cells appear amin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688859/ https://www.ncbi.nlm.nih.gov/pubmed/31259691 http://dx.doi.org/10.7554/eLife.44795 |