The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

One of the most central questions about the repair of a double-strand DNA break (DSB) concerns how the two free DNA ends are brought together — a step called synapsis. Using single-molecule FRET (smFRET), we show here that both Ku plus XRCC4:DNA ligase IV are necessary and sufficient to achieve a fl...

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Detalles Bibliográficos
Autores principales: Zhao, Bailin, Watanabe, Go, Morten, Michael J., Reid, Dylan A., Rothenberg, Eli, Lieber, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688983/
https://www.ncbi.nlm.nih.gov/pubmed/31399561
http://dx.doi.org/10.1038/s41467-019-11507-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688983/
https://www.ncbi.nlm.nih.gov/pubmed/31399561
http://dx.doi.org/10.1038/s41467-019-11507-z

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