Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 is the most evolutionarily conserved member in the caspase family of proteases and is constitutively expressed in most cell types including neurons; however, its physiological function remains largely unknown. Here we report that caspase-2 plays a critical role in synaptic plasticity and c...

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Detalles Bibliográficos
Autores principales: Xu, Zhi-Xiang, Tan, Ji-Wei, Xu, Haifei, Hill, Cassandra J., Ostrovskaya, Olga, Martemyanov, Kirill A., Xu, Baoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689033/
https://www.ncbi.nlm.nih.gov/pubmed/31399584
http://dx.doi.org/10.1038/s41467-019-11575-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689033/
https://www.ncbi.nlm.nih.gov/pubmed/31399584
http://dx.doi.org/10.1038/s41467-019-11575-1

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