Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) shows a high level of basal autophagy. Here we investigated the role of optineurin (OPTN) in PDAC cell lines, which is a prominent member of the autophagy system. To that purpose, mining of publically available databases showed that OPTN is highly expressed in...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Doaa M., Ansari, Shariq S., Zepp, Michael, Knapp-Mohammady, Michaela, Berger, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689035/
https://www.ncbi.nlm.nih.gov/pubmed/31428460
http://dx.doi.org/10.1038/s41420-019-0206-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689035/
https://www.ncbi.nlm.nih.gov/pubmed/31428460
http://dx.doi.org/10.1038/s41420-019-0206-2

Ejemplares similares