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Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) shows a high level of basal autophagy. Here we investigated the role of optineurin (OPTN) in PDAC cell lines, which is a prominent member of the autophagy system. To that purpose, mining of publically available databases showed that OPTN is highly expressed in...

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Detalles Bibliográficos
Autores principales:	Ali, Doaa M., Ansari, Shariq S., Zepp, Michael, Knapp-Mohammady, Michaela, Berger, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689035/ https://www.ncbi.nlm.nih.gov/pubmed/31428460 http://dx.doi.org/10.1038/s41420-019-0206-2

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