The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range

The molecular chaperone Hsp90 is an important regulator of proteostasis. It has remained unclear why S. cerevisiae possesses two Hsp90 isoforms, the constitutively expressed Hsc82 and the stress-inducible Hsp82. Here, we report distinct differences despite a sequence identity of 97%. Consistent with...

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Detalles Bibliográficos
Autores principales: Girstmair, Hannah, Tippel, Franziska, Lopez, Abraham, Tych, Katarzyna, Stein, Frank, Haberkant, Per, Schmid, Philipp Werner Norbert, Helm, Dominic, Rief, Matthias, Sattler, Michael, Buchner, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689086/
https://www.ncbi.nlm.nih.gov/pubmed/31399574
http://dx.doi.org/10.1038/s41467-019-11518-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689086/
https://www.ncbi.nlm.nih.gov/pubmed/31399574
http://dx.doi.org/10.1038/s41467-019-11518-w

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