Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Membrane transporters and receptors are responsible for balancing nutrient and metabolite levels to aid body homeostasis. Here, we report that proximal tubule cells in kidneys sense elevated endogenous, gut microbiome-derived, metabolite levels through EGF receptors and downstream signaling to induc...

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Detalles Bibliográficos
Autores principales: Jansen, Jitske, Jansen, Katja, Neven, Ellen, Poesen, Ruben, Othman, Amr, van Mil, Alain, Sluijter, Joost, Sastre Torano, Javier, Zaal, Esther A., Berkers, Celia R., Esser, Diederik, Wichers, Harry J., van Ede, Karin, van Duursen, Majorie, Burtey, Stéphane, Verhaar, Marianne C., Meijers, Björn, Masereeuw, Rosalinde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689987/
https://www.ncbi.nlm.nih.gov/pubmed/31341083
http://dx.doi.org/10.1073/pnas.1821809116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689987/
https://www.ncbi.nlm.nih.gov/pubmed/31341083
http://dx.doi.org/10.1073/pnas.1821809116

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