Homologous recombination defects and how they affect replication fork maintenance

Homologous recombination (HR) repairs DNA double strand breaks (DSBs) and stabilizes replication forks (RFs). RAD51 is the recombinase for the HR pathway. To preserve genomic integrity, RAD51 forms a filament on the 3′ end of a DSB and on a single-stranded DNA (ssDNA) gap. But unregulated HR results...

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Detalles Bibliográficos
Autores principales: Son, Mi Young, Hasty, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690234/
https://www.ncbi.nlm.nih.gov/pubmed/31435521
http://dx.doi.org/10.3934/genet.2018.4.192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690234/
https://www.ncbi.nlm.nih.gov/pubmed/31435521
http://dx.doi.org/10.3934/genet.2018.4.192

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