Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells

HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS). Specific increases of...

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Detalles Bibliográficos
Autores principales: Morshneva, Alisa, Gnedina, Olga, Svetlikova, Svetlana, Pospelov, Valery, Igotti, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIMS Press 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690250/
https://www.ncbi.nlm.nih.gov/pubmed/31435511
http://dx.doi.org/10.3934/genet.2018.1.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690250/
https://www.ncbi.nlm.nih.gov/pubmed/31435511
http://dx.doi.org/10.3934/genet.2018.1.41

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