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Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells
HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS). Specific increases of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
AIMS Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690250/ https://www.ncbi.nlm.nih.gov/pubmed/31435511 http://dx.doi.org/10.3934/genet.2018.1.41 |