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Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity
TMEM16F is activated by elevated intracellular Ca(2+), and functions as a small-conductance ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-, anion-, or non-selective ion channel...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690719/ https://www.ncbi.nlm.nih.gov/pubmed/31318330 http://dx.doi.org/10.7554/eLife.45187 |