Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study

BACKGROUND: Progression time from islet autoimmunity to clinical type 1 diabetes is highly variable and the extent that genetic factors contribute is unknown. METHODS: In 341 islet autoantibody-positive children with the human leucocyte antigen (HLA) DR3/DR4-DQ8 or the HLA DR4-DQ8/DR4-DQ8 genotype f...

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Detalles Bibliográficos
Autores principales: Beyerlein, Andreas, Bonifacio, Ezio, Vehik, Kendra, Hippich, Markus, Winkler, Christiane, Frohnert, Brigitte I, Steck, Andrea K, Hagopian, William A, Krischer, Jeffrey P, Lernmark, Åke, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Rich, Stephen S, Ziegler, Anette-G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690814/
https://www.ncbi.nlm.nih.gov/pubmed/30287597
http://dx.doi.org/10.1136/jmedgenet-2018-105532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690814/
https://www.ncbi.nlm.nih.gov/pubmed/30287597
http://dx.doi.org/10.1136/jmedgenet-2018-105532

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