Cargando…

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study

BACKGROUND: Progression time from islet autoimmunity to clinical type 1 diabetes is highly variable and the extent that genetic factors contribute is unknown. METHODS: In 341 islet autoantibody-positive children with the human leucocyte antigen (HLA) DR3/DR4-DQ8 or the HLA DR4-DQ8/DR4-DQ8 genotype f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beyerlein, Andreas, Bonifacio, Ezio, Vehik, Kendra, Hippich, Markus, Winkler, Christiane, Frohnert, Brigitte I, Steck, Andrea K, Hagopian, William A, Krischer, Jeffrey P, Lernmark, Åke, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Rich, Stephen S, Ziegler, Anette-G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690814/ https://www.ncbi.nlm.nih.gov/pubmed/30287597 http://dx.doi.org/10.1136/jmedgenet-2018-105532

Ejemplares similares

Early Infant Diet and Islet Autoimmunity in the TEDDY Study
por: Uusitalo, Ulla, et al.
Publicado: (2018)

Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children
por: Bonifacio, Ezio, et al.
Publicado: (2018)

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
por: Li, Qian, et al.
Publicado: (2020)

Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
por: Elding Larsson, Helena, et al.
Publicado: (2017)

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
por: Hippich, Markus, et al.
Publicado: (2019)

The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study
por: Törn, Carina, et al.
Publicado: (2015)

Analgesic antipyretic use among young children in the TEDDY study: no association with islet autoimmunity
por: Lundgren, Markus, et al.
Publicado: (2017)

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
por: Salami, Falastin, et al.
Publicado: (2022)

Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
por: Elding Larsson, Helena, et al.
Publicado: (2016)

Complement gene variants in relation to autoantibodies to beta cell specific antigens and type 1 diabetes in the TEDDY Study
por: Törn, Carina, et al.
Publicado: (2016)

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study
por: Auchtung, Thomas A., et al.
Publicado: (2022)

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens
por: Krischer, Jeffrey P., et al.
Publicado: (2023)

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
por: Törn, Carina, et al.
Publicado: (2022)

Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study
por: Mattila, Markus, et al.
Publicado: (2019)

A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY
por: Lönnrot, Maria, et al.
Publicado: (2015)

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
por: Vatanen, Tommi, et al.
Publicado: (2018)

Temporal development of the gut microbiome in early childhood from the TEDDY study
por: Stewart, Christopher J., et al.
Publicado: (2018)

Metabolite-related dietary patterns and the development of islet autoimmunity
por: Johnson, Randi K., et al.
Publicado: (2019)

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
por: Lindfors, Katri, et al.
Publicado: (2020)

Prevalence of Obesity was Related to HLA-DQ in 2–4 Year Old Children at Genetic Risk for Type 1 Diabetes
por: Yang, Jimin, et al.
Publicado: (2014)

Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort
por: Sharma, Ashok, et al.
Publicado: (2016)

Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
por: Niinistö, Sari, et al.
Publicado: (2021)

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes
por: Vehik, Kendra, et al.
Publicado: (2019)

Beta cell function in participants with single or multiple islet autoantibodies at baseline in the TEDDY Family Prevention Study: TEFA
por: Martinez, Maria Månsson, et al.
Publicado: (2020)

Heterogeneity of beta-cell function in subjects with multiple islet autoantibodies in the TEDDY family prevention study - TEFA
por: Martinez, Maria Månsson, et al.
Publicado: (2022)

Intake of energy and protein is associated with overweight risk at age 5.5 years: Results from the prospective TEDDY study
por: Beyerlein, Andreas, et al.
Publicado: (2017)

Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes
por: Kwon, Bum Chul, et al.
Publicado: (2022)

Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes
por: Kemppainen, Kaisa M., et al.
Publicado: (2015)

25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children: A Case–Control Study
por: Andrén Aronsson, Carin, et al.
Publicado: (2021)

Early Probiotic Supplementation and the Risk of Celiac Disease in Children at Genetic Risk
por: Uusitalo, Ulla, et al.
Publicado: (2019)

Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection
por: Lin, Jake, et al.
Publicado: (2023)

Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study
por: Mehta, Pooja, et al.
Publicado: (2023)

Complete blood counts with red blood cell determinants associate with reduced beta‐cell function in seroconverted Swedish TEDDY children
por: Salami, Falastin, et al.
Publicado: (2021)

Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)
por: Waugh, Kathleen, et al.
Publicado: (2017)

Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children
por: Ng, Kenney, et al.
Publicado: (2022)

Etiology of Autoimmune Islet Disease: Timing Is Everything
por: Lernmark, Åke
Publicado: (2021)

Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
por: Nakayasu, Ernesto S., et al.
Publicado: (2023)

Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics
por: Sterner, Y, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8uknj2urn89l9vgs14s3n61epr