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Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
Tropane alkaloids (TAs) are a class of phytochemicals produced by plants of the nightshade family used for treating diverse neurological disorders. Here, we demonstrate de novo production of tropine, a key intermediate in the biosynthetic pathway of medicinal TAs such as scopolamine, from simple car...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690885/ https://www.ncbi.nlm.nih.gov/pubmed/31406117 http://dx.doi.org/10.1038/s41467-019-11588-w |