Stress-induced phospho-ubiquitin formation causes parkin degradation

Mutations in the E3 ubiquitin ligase parkin are the most common known cause of autosomal recessive Parkinson’s disease (PD), and parkin depletion may play a role in sporadic PD. Here, we sought to elucidate the mechanisms by which stress decreases parkin protein levels using cultured neuronal cells...

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Detalles Bibliográficos
Autores principales: Kovalchuke, Lyudmila, Mosharov, Eugene V., Levy, Oren A., Greene, Lloyd A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690910/
https://www.ncbi.nlm.nih.gov/pubmed/31406131
http://dx.doi.org/10.1038/s41598-019-47952-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690910/
https://www.ncbi.nlm.nih.gov/pubmed/31406131
http://dx.doi.org/10.1038/s41598-019-47952-5

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