Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative

OBJECTIVE: The rational combination of immunotherapy with standard chemotherapy shows synergistic clinical activities in cancer treatment. In the present study, an oral powder formulation of pemetrexed (PMX) was developed to enhance intestinal membrane permeability and investigate its application in...

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Detalles Bibliográficos
Autores principales: Pangeni, Rudra, Jha, Saurav Kumar, Maharjan, Ruby, Choi, Jeong Uk, Chang, Kwan-Young, Choi, Young Kweon, Byun, Youngro, Park, Jin Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690926/
https://www.ncbi.nlm.nih.gov/pubmed/31496690
http://dx.doi.org/10.2147/IJN.S209722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690926/
https://www.ncbi.nlm.nih.gov/pubmed/31496690
http://dx.doi.org/10.2147/IJN.S209722

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