Cargando…

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

Imbalanced angiogenesis is a characteristic of several diseases. Rho GTPases regulate multiple cellular processes, such as cytoskeletal rearrangement, cell movement, microtubule dynamics, signal transduction and gene expression. Among the Rho GTPases, RhoA, Rac1 and Cdc42 are best characterized. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zahra, Fatema Tuz, Sajib, Md Sanaullah, Ichiyama, Yusuke, Akwii, Racheal Grace, Tullar, Paul E., Cobos, Christopher, Minchew, Shelby A., Doçi, Colleen L., Zheng, Yi, Kubota, Yoshiaki, Gutkind, J. Silvio, Mikelis, Constantinos M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690958/ https://www.ncbi.nlm.nih.gov/pubmed/31406143 http://dx.doi.org/10.1038/s41598-019-48053-z

Ejemplares similares

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology
por: Akwii, Racheal G., et al.
Publicado: (2019)

Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
por: Zahra, Fatema Tuz, et al.
Publicado: (2021)

Targeting the Angiopoietin/Tie Pathway: Prospects for Treatment of Retinal and Respiratory Disorders
por: Akwii, Racheal Grace, et al.
Publicado: (2021)

Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro
por: Hossian, A. K. M. Nawshad, et al.
Publicado: (2018)

The role of RhoA/Rho kinase pathway in endothelial dysfunction
por: Yao, Lin, et al.
Publicado: (2010)

Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activating RhoA and Rac1 GTPase
por: Lv, Qingyu, et al.
Publicado: (2014)

Low Dose of Penfluridol Inhibits VEGF-Induced Angiogenesis
por: Srivastava, Suyash, et al.
Publicado: (2020)

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
por: Mikelis, Constantinos M., et al.
Publicado: (2015)

RhoA, RhoB and RhoC differentially regulate endothelial barrier function
por: Pronk, Manon C. A., et al.
Publicado: (2017)

Protocol for structural and biochemical analyses of RhoA GTPase
por: Lin, Yuan, et al.
Publicado: (2021)

RhoA of the Rho Family Small GTPases Is Essential for B Lymphocyte Development
por: Zhang, Shuangmin, et al.
Publicado: (2012)

Role of Small GTPase RhoA in DNA Damage Response
por: Cheng, Chibin, et al.
Publicado: (2021)

Structure of human TRPV4 in complex with GTPase RhoA
por: Nadezhdin, Kirill D., et al.
Publicado: (2023)

RhoB controls endothelial cell morphogenesis in part via negative regulation of RhoA
por: Howe, Grant A, et al.
Publicado: (2012)

Roles of the small GTPases RhoA and Rac1 in cell behavior
por: Otey, Carol, et al.
Publicado: (2009)

The Small GTPase RhoA Is Required for Proper Locomotor Circuit Assembly
por: Mulherkar, Shalaka, et al.
Publicado: (2013)

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors
por: Zhou, Xuan, et al.
Publicado: (2013)

RhoA GTPase inhibition organizes contraction during epithelial morphogenesis
por: Mason, Frank M., et al.
Publicado: (2016)

Regulation of smooth muscle contraction by monomeric non‐RhoA GTPases
por: Li, Bingsheng, et al.
Publicado: (2020)

Rho-GTPase signaling in leukocyte extravasation: An endothelial point of view
por: Heemskerk, Niels, et al.
Publicado: (2014)

Conserved roles for yeast Rho1 and mammalian RhoA GTPases in clathrin-independent endocytosis
por: Prosser, Derek C., et al.
Publicado: (2012)

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
por: Jackson, Ben, et al.
Publicado: (2011)

Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA
por: Thakar, Ketan, et al.
Publicado: (2017)

Modelling GTPase dynamics to understand RhoA-driven cancer cell invasion
por: Hetmanski, Joseph H.R., et al.
Publicado: (2016)

Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling
por: van der Krogt, Jeffrey MA, et al.
Publicado: (2023)

Inactivating Mutations in GNA13 and RHOA in Burkitt’s Lymphoma and Diffuse Large B cell Lymphoma: A Tumor Suppressor Function for the Gα(13)/RhoA Axis in B Cells
por: O’Hayre, Morgan, et al.
Publicado: (2015)

Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells
por: Reinhard, Nathalie R., et al.
Publicado: (2016)

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK
por: Salinas, Romina P., et al.
Publicado: (2015)

Crystal structures of the PH domains from Lbc family of RhoGEFs bound to activated RhoA GTPase
por: Chen, Zhe, et al.
Publicado: (2018)

RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia
por: Leslie, Jennifer R., et al.
Publicado: (2012)

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases
por: Jou, Tzuu-Shuh, et al.
Publicado: (1998)

Structural Insights into the Activation of the RhoA GTPase by the Lymphoid Blast Crisis (Lbc) Oncoprotein
por: Lenoir, Marc, et al.
Publicado: (2014)

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation
por: Roh-Johnson, Minna, et al.
Publicado: (2013)

Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling
por: Inaba, Hironori, et al.
Publicado: (2021)

The RhoA GTPase regulates Type I Interferon Signaling in Systemic lupus erythematosus
por: Fan, Wei, et al.
Publicado: (2023)

The Small GTPase RhoB Regulates TNFα Signaling in Endothelial Cells
por: Kroon, Jeffrey, et al.
Publicado: (2013)

Activation of RhoA/Rho-kinase pathway accounts for pulmonary endothelial dysfunction in patients with chronic obstructive pulmonary disease
por: Bei, Yihua, et al.
Publicado: (2013)

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors
por: Boyer, Laurent, et al.
Publicado: (2006)

RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response
por: Wang, Jiping, et al.
Publicado: (2012)

Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells
por: Zhu, Ying-Ting, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4kqtfk7bcu65ue50fqvdf4sto7