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Link clustering explains non-central and contextually essential genes in protein interaction networks

Recent studies have shown that many essential genes (EGs) change their essentiality across various contexts. Finding contextual EGs in pathogenic conditions may facilitate the identification of therapeutic targets. We propose link clustering as an indicator of contextual EGs that are non-central in...

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Detalles Bibliográficos
Autores principales: Kim, Inhae, Lee, Heetak, Lee, Kwanghwan, Han, Seong Kyu, Kim, Donghyo, Kim, Sanguk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690968/
https://www.ncbi.nlm.nih.gov/pubmed/31406201
http://dx.doi.org/10.1038/s41598-019-48273-3