Cargando…
Alleviation of sepsis-induced cardiac dysfunction by overexpression of Sestrin2 is associated with inhibition of p-S6K and activation of the p-AMPK pathway
Sepsis-induced myocardial injury is one of the manifestations of multiple organ dysfunction in sepsis. The aim of the present study was to determine the mechanism of alleviation of lipopolysaccharide (LPS)-induced injury on cardiomyocytes by Sestrin2. A sepsis model using LPS injection was construct...
Autores principales: | Wang, Ziwen, Bu, Lin, Yang, Peng, Feng, Shoujie, Xu, Feng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691248/ https://www.ncbi.nlm.nih.gov/pubmed/31524263 http://dx.doi.org/10.3892/mmr.2019.10520 |
Ejemplares similares
-
Knockout of AMPKα2 Blocked the Protection of Sestrin2 Overexpression Against Cardiac Hypertrophy Induced by Pressure Overload
por: Zhang, Nan, et al.
Publicado: (2021) -
Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway
por: Huang, Wei, et al.
Publicado: (2017) -
Sestrin-2 regulates podocyte mitochondrial dysfunction and apoptosis under high-glucose conditions via AMPK
por: Lin, Qiaoxuan, et al.
Publicado: (2020) -
The promotion of sestrin2/AMPK signaling by HIF-1α overexpression enhances the damage caused by acute myocardial infarction
por: Wang, Jie, et al.
Publicado: (2023) -
Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression
por: Zhu, Xiao Geng, et al.
Publicado: (2020)