Simulation of heterogeneous tumour genomes with HeteroGenesis and in silico whole exome sequencing

SUMMARY: Tumour evolution results in progressive cancer phenotypes such as metastatic spread and treatment resistance. To better treat cancers, we must characterize tumour evolution and the genetic events that confer progressive phenotypes. This is facilitated by high coverage genome or exome sequen...

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Detalles Bibliográficos
Autores principales: Tanner, Georgette, Westhead, David R, Droop, Alastair, Stead, Lucy F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691334/
https://www.ncbi.nlm.nih.gov/pubmed/30615054
http://dx.doi.org/10.1093/bioinformatics/bty1063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691334/
https://www.ncbi.nlm.nih.gov/pubmed/30615054
http://dx.doi.org/10.1093/bioinformatics/bty1063

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