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Simulation of heterogeneous tumour genomes with HeteroGenesis and in silico whole exome sequencing
SUMMARY: Tumour evolution results in progressive cancer phenotypes such as metastatic spread and treatment resistance. To better treat cancers, we must characterize tumour evolution and the genetic events that confer progressive phenotypes. This is facilitated by high coverage genome or exome sequen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691334/ https://www.ncbi.nlm.nih.gov/pubmed/30615054 http://dx.doi.org/10.1093/bioinformatics/bty1063 |