Cargando…

Modulation of Respiration and Mitochondrial Dynamics by SMAC-Mimetics for Combination Therapy in Chemoresistant Cancer

Inhibitor of apoptosis proteins (IAP) are cell death regulators that bind caspases and interfere with apoptotic signalling via death receptors or intrinsic cell death pathways. BIRC4/XIAP is the most potent anti-apoptotic IAP-member and it physically interacts with caspases via its BIR2 and its BIR3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hagenbuchner, Judith, Oberacher, Herbert, Arnhard, Kathrin, Kiechl-Kohlendorfer, Ursula, Ausserlechner, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691393/ https://www.ncbi.nlm.nih.gov/pubmed/31410190 http://dx.doi.org/10.7150/thno.33758

Ejemplares similares

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration
por: Hagenbuchner, Judith, et al.
Publicado: (2013)

The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastoma
por: Hagenbuchner, Judith, et al.
Publicado: (2017)

FOXO3/FKHRL1 is activated by 5-aza-2-deoxycytidine and induces silenced caspase-8 in neuroblastoma
por: Geiger, Kathrin, et al.
Publicado: (2012)

Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma
por: Hagenbuchner, Judith, et al.
Publicado: (2016)

C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma
por: Salcher, Stefan, et al.
Publicado: (2014)

FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3
por: Rupp, M, et al.
Publicado: (2017)

Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP)
por: Seiter, Maximilian A., et al.
Publicado: (2014)

Future Therapeutic Directions for Smac-Mimetics
por: Morrish, Emma, et al.
Publicado: (2020)

New light on Smac mimetics and breast cancer
por: Cornmark, L, et al.
Publicado: (2016)

Hyperosmotic stress enhances cytotoxicity of SMAC mimetics
por: Bittner, Sebastian, et al.
Publicado: (2017)

SMAC Mimetics as Therapeutic Agents in HIV Infection
por: Molyer, Bengisu, et al.
Publicado: (2021)

C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy
por: Salcher, S., et al.
Publicado: (2017)

Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic
por: Balakrishnan, Kumudha, et al.
Publicado: (2016)

Repaglinide Silences the FOXO3/Lumican Axis and Represses the Associated Metastatic Potential of Neuronal Cancer Cells
por: Salcher, Stefan, et al.
Publicado: (2019)

Redox regulation of Smac mimetic-induced cell death
por: Fulda, Simone
Publicado: (2015)

Smac-mimetics reduce numbers and viability of human osteoclasts
por: Moen, Ingrid Nyhus, et al.
Publicado: (2021)

Smac mimetics induce inflammation and necrotic tumour cell death by modulating macrophage activity
por: Lecis, D, et al.
Publicado: (2013)

The role of SMAC mimetics in regulation of tumor cell death and immunity
por: Emeagi, Perpetua U., et al.
Publicado: (2012)

Regulation of cancer stem-like cell differentiation by Smac mimetics
por: Fulda, Simone
Publicado: (2014)

Targeting triple-negative breast cancers with the Smac-mimetic birinapant
por: Lalaoui, Najoua, et al.
Publicado: (2020)

Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy
por: Zhao, Xiao-Yun, et al.
Publicado: (2020)

Redirecting neutrophils against bladder cancer cells by BCG and Smac mimetic combination
por: Jinesh G., Goodwin, et al.
Publicado: (2012)

Mitochondria and FOXO3: breath or die
por: Hagenbuchner, Judith, et al.
Publicado: (2013)

Very long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery
por: Hagenbuchner, Judith, et al.
Publicado: (2018)

A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma
por: Salcher, Stefan, et al.
Publicado: (2019)

Analysis of Mitochondrial Function, Structure, and Intracellular Organization In Situ in Cardiomyocytes and Skeletal Muscles
por: Kuznetsov, Andrey V., et al.
Publicado: (2022)

SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds
por: Cheung, H H, et al.
Publicado: (2011)

Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer
por: Awasthi, Niranjan, et al.
Publicado: (2011)

Smac mimetics and innate immune stimuli synergize to promote tumor death
por: Beug, Shawn T., et al.
Publicado: (2014)

The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP
por: Huang, Qingsheng, et al.
Publicado: (2019)

Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis
por: Kulíšková, Petra, et al.
Publicado: (2023)

Novel SMAC-mimetics synergistically stimulate melanoma cell death in combination with TRAIL and Bortezomib
por: Lecis, D, et al.
Publicado: (2010)

Activity of Birinapant, a SMAC Mimetic Compound, Alone or in Combination in NSCLCs With Different Mutations
por: Colombo, Marika, et al.
Publicado: (2020)

Inhibition of Autophagy and the Cytoprotective Role of Smac Mimetic against ROS-Induced Cancer: A Potential Therapeutic Strategy in Relapse and Chemoresistance Cases in Breast Cancer
por: Rafat, Sahar, et al.
Publicado: (2023)

3D bioprinting: novel approaches for engineering complex human tissue equivalents and drug testing
por: Hagenbuchner, Judith, et al.
Publicado: (2021)

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma
por: Crawford, N, et al.
Publicado: (2013)

Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells
por: Czaplinski, Sebastian, et al.
Publicado: (2015)

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
por: Abhari, Behnaz Ahangarian, et al.
Publicado: (2019)

SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages
por: Campbell, Grant R., et al.
Publicado: (2020)

Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant
por: Fichtner, Michael, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_rsii766gvp19go42clomq89eem