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Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma

INTRODUCTION: Phosphodiesterase inhibitors (PDEs) increase intracellular cyclic adenosine monophosphate, which results in a wide range of anti-inflammatory effects and pathologically leads to improve asthma disease. Because no human study has surveyed the effect of PDEs on pulmonary function, except...

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Autores principales: Borsi, Hamid, Raji, Hanieh, Shoushtari, Maryam Haddadzadeh, Tavakol, Heshmatollah, Haghighizadeh, Mohammad Hossein, Mal-Amir, Mehrdad Dargahi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691445/
https://www.ncbi.nlm.nih.gov/pubmed/31463257
http://dx.doi.org/10.4103/jfmpc.jfmpc_334_19
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author Borsi, Hamid
Raji, Hanieh
Shoushtari, Maryam Haddadzadeh
Tavakol, Heshmatollah
Haghighizadeh, Mohammad Hossein
Mal-Amir, Mehrdad Dargahi
author_facet Borsi, Hamid
Raji, Hanieh
Shoushtari, Maryam Haddadzadeh
Tavakol, Heshmatollah
Haghighizadeh, Mohammad Hossein
Mal-Amir, Mehrdad Dargahi
author_sort Borsi, Hamid
collection PubMed
description INTRODUCTION: Phosphodiesterase inhibitors (PDEs) increase intracellular cyclic adenosine monophosphate, which results in a wide range of anti-inflammatory effects and pathologically leads to improve asthma disease. Because no human study has surveyed the effect of PDEs on pulmonary function, except some case reports and animal researches, we decided to perform a pilot study for evaluating the effect of sildenafil (PDE5) on pulmonary function in patients with severe asthma. METHODS: This randomized controlled trials study was conducted on 20 patients with severe asthma in 2019 in Iran. For case group, was prescribed sildenafil (50 mg) daily and the control group received the placebo. In the beginning of the study and one month later, volume parameters, 6-minute walk distance (6MWD), and the quality-of-life questionnaire were measured and compared in the two groups. RESULTS: Twenty patients were entered into this study. 8 patients (40%) were male and 12 (60%) were female. The results showed that mean forced vital capacity 1 in the sildenafil group turned from 1259 ± 170 to 1603 ± 527, while in the placebo group it changed from 1135 ± 125 to 1365 ± 251 (P-value = 0.215). There is no statistically significant difference between two groups. In addition, in comparison with placebo, sildenafil did not show any significant improvement in the volume parameters, the quality-of-life questionnaire scale, and 6MWD at the end of the study. CONCLUSION: According to present result can be concluded that sildenafil does not improve the severity of asthma and the quality of life in patients with severe asthma.
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spelling pubmed-66914452019-08-28 Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma Borsi, Hamid Raji, Hanieh Shoushtari, Maryam Haddadzadeh Tavakol, Heshmatollah Haghighizadeh, Mohammad Hossein Mal-Amir, Mehrdad Dargahi J Family Med Prim Care Original Article INTRODUCTION: Phosphodiesterase inhibitors (PDEs) increase intracellular cyclic adenosine monophosphate, which results in a wide range of anti-inflammatory effects and pathologically leads to improve asthma disease. Because no human study has surveyed the effect of PDEs on pulmonary function, except some case reports and animal researches, we decided to perform a pilot study for evaluating the effect of sildenafil (PDE5) on pulmonary function in patients with severe asthma. METHODS: This randomized controlled trials study was conducted on 20 patients with severe asthma in 2019 in Iran. For case group, was prescribed sildenafil (50 mg) daily and the control group received the placebo. In the beginning of the study and one month later, volume parameters, 6-minute walk distance (6MWD), and the quality-of-life questionnaire were measured and compared in the two groups. RESULTS: Twenty patients were entered into this study. 8 patients (40%) were male and 12 (60%) were female. The results showed that mean forced vital capacity 1 in the sildenafil group turned from 1259 ± 170 to 1603 ± 527, while in the placebo group it changed from 1135 ± 125 to 1365 ± 251 (P-value = 0.215). There is no statistically significant difference between two groups. In addition, in comparison with placebo, sildenafil did not show any significant improvement in the volume parameters, the quality-of-life questionnaire scale, and 6MWD at the end of the study. CONCLUSION: According to present result can be concluded that sildenafil does not improve the severity of asthma and the quality of life in patients with severe asthma. Wolters Kluwer - Medknow 2019-07 /pmc/articles/PMC6691445/ /pubmed/31463257 http://dx.doi.org/10.4103/jfmpc.jfmpc_334_19 Text en Copyright: © 2019 Journal of Family Medicine and Primary Care http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Borsi, Hamid
Raji, Hanieh
Shoushtari, Maryam Haddadzadeh
Tavakol, Heshmatollah
Haghighizadeh, Mohammad Hossein
Mal-Amir, Mehrdad Dargahi
Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
title Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
title_full Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
title_fullStr Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
title_full_unstemmed Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
title_short Investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
title_sort investigating the effect of sildenafil on improving lung function and quality of life in the patients with severe asthma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691445/
https://www.ncbi.nlm.nih.gov/pubmed/31463257
http://dx.doi.org/10.4103/jfmpc.jfmpc_334_19
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