Hybrid micelles containing methotrexate-conjugated polymer and co-loaded with microRNA-124 for rheumatoid arthritis therapy

Purpose: Methotrexate (MTX) is a first-line drug for rheumatoid arthritis (RA)therapy. However, MTX monotherapy often results in irreversible joint damage due to its slow onset of action and long duration. microRNA-124 (miR-124) has shown direct bone protection activity against RA. A co-delivery sys...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Fei, Lee, Robert J, Zhong, Lihuang, Dong, Shiyan, Yang, Chunmiao, Teng, Lirong, Meng, Qingfan, Lu, Jiahui, Xie, Jing, Teng, Lesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691571/
https://www.ncbi.nlm.nih.gov/pubmed/31410215
http://dx.doi.org/10.7150/thno.32268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691571/
https://www.ncbi.nlm.nih.gov/pubmed/31410215
http://dx.doi.org/10.7150/thno.32268

Ejemplares similares