Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor

BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the years, small molecules targeting BRAFV600E have bee...

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Detalles Bibliográficos
Autores principales: Kim, Jinwoong, Choi, Byeongha, Im, Daseul, Jung, Hoyong, Moon, Hyungwoo, Aman, Waqar, Hah, Jung-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691785/
https://www.ncbi.nlm.nih.gov/pubmed/31307243
http://dx.doi.org/10.1080/14756366.2019.1599366

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691785/
https://www.ncbi.nlm.nih.gov/pubmed/31307243
http://dx.doi.org/10.1080/14756366.2019.1599366

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