Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited ex...

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Detalles Bibliográficos
Autores principales: Elmeligie, Salwa, Aboul-Magd, Asmaa M., Lasheen, Deena S., Ibrahim, Tamer M., Abdelghany, Tamer M., Khojah, Sohair M., Abouzid, Khaled A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691788/
https://www.ncbi.nlm.nih.gov/pubmed/31322015
http://dx.doi.org/10.1080/14756366.2019.1642883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691788/
https://www.ncbi.nlm.nih.gov/pubmed/31322015
http://dx.doi.org/10.1080/14756366.2019.1642883

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