Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a key enzyme in the biosynthesis of 17β-estradiol. Novel estrone-based compounds bearing various 15β-oxa-linked substituents and hydroxy, methoxy, benzyloxy, and sulfamate groups in position C3 as potential 17β-HSD1 inhibitors have been synthesiz...

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Detalles Bibliográficos
Autores principales: Herman, Bianka Edina, Kiss, Anita, Wölfling, János, Mernyák, Erzsébet, Szécsi, Mihály, Schneider, Gyula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691805/
https://www.ncbi.nlm.nih.gov/pubmed/31307240
http://dx.doi.org/10.1080/14756366.2019.1634064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691805/
https://www.ncbi.nlm.nih.gov/pubmed/31307240
http://dx.doi.org/10.1080/14756366.2019.1634064

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