Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice

Context: Neuroligin-1 (NLGN1) is a cell adhesion protein located on the excitatory postsynaptic membrane. β-Amyloid (Aβ)-induced neuroinflammation decreases NLGN1 expression through epigenetic mechanisms. Triptolide (T10) and tripchlorolide (T4) exert protective effects on synapses in Alzheimer'...

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Detalles Bibliográficos
Autores principales: Lu, Xiaomei, Yang, Baolin, Yu, Hao, Hu, Xiaoling, Nie, Jing, Wan, Bin, Zhang, Ming, Lü, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691810/
https://www.ncbi.nlm.nih.gov/pubmed/31311385
http://dx.doi.org/10.1080/13880209.2019.1629463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691810/
https://www.ncbi.nlm.nih.gov/pubmed/31311385
http://dx.doi.org/10.1080/13880209.2019.1629463

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