Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors

Neratinib is an oral pan HER inhibitor, that irreversibly inhibits EGFR and HER2 and was proven to be effective against multiple EGFR mutations. In previous study, we reported spiro [indoline-3, 4′-piperidine]-2-ones as anticancer agents. In this study, we designed aminopyridine-containing spiro [in...

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Detalles Bibliográficos
Autores principales: Ye, Lianbao, Zhao, Tao, Du, Wenjun, Li, Anhu, Gao, Wei, Li, Jingrong, Wang, Ling, Chen, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691816/
https://www.ncbi.nlm.nih.gov/pubmed/31286784
http://dx.doi.org/10.1080/14756366.2019.1634704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691816/
https://www.ncbi.nlm.nih.gov/pubmed/31286784
http://dx.doi.org/10.1080/14756366.2019.1634704

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